Myeloproliferative neoplasms and pregnancy

Introduction. The Myeloproliferative Neoplasms are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by increased proliferation the myeloid lineages in bone marrow. A particular clinical challenge is presented certain situations patients with myeloproliferative Neoplasms, which we do not encounter daily. For this reason, paper, will emphasize approach to overcoming obstacles specific settings, like pregnancy. Pregnancy Philadelphia chromosome-negative has been reported be associated maternal thrombosis, hemorrhage, and placental dysfunction leading fetal growth restriction or loss. Thrombocytosis, leucocytosis, high level hematocrit, activation Platelets, leucocytes, circulating pro-thrombotic connected pathogenesis thrombosis MPNs With survival expectations similar age-matched controls excellent response worldwide access tyrosine kinase inhibitors, family planning increasingly important for many chronic leukemia. All were managed multidisciplinary team physicians obligatory hematological gynecologistsobstetrician consultations.